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For decades, we’ve been told that Alzheimer’s disease is caused primarily by the buildup of plaques in the brain—beta-amyloid proteins. This theory has shaped modern medicine, guided drug development, and driven billions of dollars in research. Clinical results remain modest at best. Many of these medications slightly slow decline, but often come with side effects such as brain swelling, bleeding, nausea, and confusion. It makes you step back and ask if we are truly addressing the root cause, or just one piece of a much larger puzzle?